Abstract
[long dash]The effect of Actinospectacin, a broad-spectrum antibiotic produced by Streptomyces spectabolis, in experimental syphilis in the rabbit was studied. As little as 10 mg/kg/day cured when divided into 6 equal 4-hourly intramuscular injections over a 6 day period, or when given as a single daily dose for 6 days. Single injections of 1.2 g/kg cured all subjects; 240 mg/kg did not.