THE VARIABILITY OF PROTEINURIA IN THE HYPERTENSIVE COMPLICATIONS OF PREGNANCY

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Abstract
4 urine specimens were collected at hourly intervals from 6 pregnant and 5 non-pregnant nephritics, and from 4 eclamptic and 9 pre-eclamptic patients. The conc. of urinary protein was divided by the Urine-to-Plasma ratio for endogenous creatinine. This quotient is thought to bear a constant relation to the conc. of protean in the glomerular filtrate, at least from hr. to hr. in a given subject. Thus the variability of protein filtration may be estimated. In nephritics, pregnant or not, the protein filtration showed very little variation from hr. to hr. In preeclampsia and eclampsia the protein filtration is variable. This argues for a functional cause (vascular spasms) for the proteinuria.

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