EFFECTS OF ACLACINOMYCIN-A ON MURINE LEUKEMIA

  • 1 January 1982
    • journal article
    • research article
    • Vol. 60  (1) , 188-193
Abstract
Effects of aclacinomycin A (ACM) on leukemic cells and normal hematopoietic stem cells were studied for the purpose of evaluating the usefulness of this agent as an antileukemic agent. ACM suppressed not only leukemic colony-forming units (LCFU) in the radiation-induced murine erythroleukemia, but also normal hematopoietic stem cells (CFU-S [pluripotential stem cells], CFU-C [granulocytic progenitor cells]) in mice. However, LCFU was the most sensitive to ACM. After the administration of ACM at a dose of 5 mg/kg, LCFU was suppressed to 0.02 of the control on day 3 and recovered within 5 days. Splenic CFU-S and CFU-C were suppressed to the nadirs on day 2 and day 1, respectively; they recovered within 5 days. On the basis of the differences in the sensitivities to ACM and recovery patterns between LCFU and normal hematopoietic stem cells, ACM at a single dose of 5 mg/kg was administered every 3 days (total dose of 25 mg/kg) into leukemic mice; the increase in mean lifespan was 113.9%. Effectiveness of ACM in the treatment of acute leukemia was discussed.