Some Effects of Testosterone Propionate on Mice Irradiated with X-rays.

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Abstract
Male white Swiss male weighing 22 g. received the LD50/30 days of X-ray (HVL 0.75 mm. Cu) as total body irradiation in one exposure and in addition 6 weekly injns. of 0.25 and 0.5 mg. of testosterone propionate for 2 weeks after irradiation. Androgen admn. markedly increased the lethal effect of irradiation, contrary to the admn. of desoxycorticosterone acetate. No influence on radiation induced organ changes were observed with the exception of accumulation of sudanophile fat in the liver. Testosterone propionate reduced the fat accumulation in the liver of irradiated animals significantly with the larger dose used.