Experimental Hydronephrosis: I

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Abstract
In mongrel dogs bilateral bladder pouches were constructed for the collection of urine from each kidney. The ureter of one kidney was ligated for various periods of time. Following release of unilateral obstruction, the only hydronephrotic kidney which functioned normally at the conclusion of the repair period was that kidney which had been obstructed for 4 days. None of the hydronephrotic kidneys obstructed for 7 or more days approached its original functional level. The functional state of these latter kidneys was extremely limited at the conclusion of the experiment. Functional atrophy of disuse did not occur; rather a fixed functional state persisted in those kidneys previously obstructed for 7 or more days and then followed during a repair period. Morphological atrophy of disuse did not occur in the experimental kidneys obstructed from 4 to 56 days and then allowed to repair for 63 to 144 days in competition with a normal contralateral kidney. Morphological repair did not occur in the experimental kidneys following release of the ureteral obstruction. A correlation seemed to exist between the size of the renal mass, the microscopic appearance of the kidney and the functional activity of any particular hydronephrotic kidney in the experimental group.

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