Synthesis and in vitro activity of some methylenomycin analogs.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (8) , 1061-1067
- https://doi.org/10.7164/antibiotics.38.1061
Abstract
A cationic cyclopentannelation reaction has afforded a very simple route to a wide variety of methylenomycin analogs. The antibacterial activity of these readily accessible synthetic compounds parallels that of naturally occurring methylenomycin A. The in vitro antitumor activity of the synthetics assayed using human nasopharyngeal carcinoma (KB) cells is particularly promising.This publication has 2 references indexed in Scilit:
- Fittig bislactones in cyclopentenone synthesis: short synthesis of methylenomycin BCanadian Journal of Chemistry, 1982
- A stereospecific total synthesis of (.+-.)-methylenomycin A and its epimer, (.+-.)-epimethylenomycin AJournal of the American Chemical Society, 1980