Cocaine Plasma Concentration: Relation to Physiological and Subjective Effects in Humans
- 13 October 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 202 (4364) , 227-228
- https://doi.org/10.1126/science.694530
Abstract
Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride intravenously or intranasally. There was a positive relationship between peak plasma concentration, physiological and subjective responses, and dose administered. The rate of cocaine disappearance after intravenous administration paralleled the drop in physiological and subjective drug effects. After intranasal administration, blood levels remained elevated for a considerably longer period.This publication has 6 references indexed in Scilit:
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