Multiple Global Suppressors of Protein Stability Defects Facilitate the Evolution of Extended-Spectrum TEM β-Lactamases
- 16 October 2010
- journal article
- Published by Elsevier in Journal of Molecular Biology
- Vol. 404 (5) , 832-846
- https://doi.org/10.1016/j.jmb.2010.10.008
Abstract
No abstract availableKeywords
This publication has 60 references indexed in Scilit:
- Structural Bases for Stability–Function Tradeoffs in Antibiotic ResistanceJournal of Molecular Biology, 2010
- Exploring protein fitness landscapes by directed evolutionNature Reviews Molecular Cell Biology, 2009
- Molecular mechanisms of functional rescue mediated by P53 tumor suppressor mutationsBiophysical Chemistry, 2009
- Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM‐1 β‐lactamaseProtein Science, 2009
- Stability effects of mutations and protein evolvabilityPublished by Elsevier ,2009
- In the light of directed evolution: Pathways of adaptive protein evolutionProceedings of the National Academy of Sciences, 2009
- Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-LactamaseJournal of Molecular Biology, 2008
- Protein stability promotes evolvabilityProceedings of the National Academy of Sciences, 2006
- Evolution of an Antibiotic Resistance Enzyme Constrained by Stability and Activity Trade-offsJournal of Molecular Biology, 2002
- Why are proteins marginally stable?Proteins-Structure Function and Bioinformatics, 2001