In vitro activity of ampicillin plus sulbactam against anaerobes compared to ampicillin and cefoxitin

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Abstract
The antimicrobial susceptibility of 195 recent clinical isolates of anaerobic bacteria was studied to ampicillin alone, ampicillin +1 mg/l sulbactam, ampicillin +5 mg/l sulbactam, and cefoxitin by means of agar dilution tests. The ampicillin-sulbactam combinations were the most effective drugs against species of theBacteroides fragilis group, the MIC90 of ampicillin +5 mg/l sulbactam forB. fragilis being Peptococcus spp. andPeptostreptococcus spp. with MIC's Bacteroides fragilis-Gruppe, so betrug gegenüberB. fragilis (s. s.) die MHK90 für Ampicillin +5 mg/l Sulbactam Peptococcus spp. undPeptostreptococcus spp. waren im Vergleich zwischen Ampicillin alleine und in Kombinationen mit Sulbactam keine signifikanten Unterschiede festzustellen. Die MHK90 betrug bei diesen Keimen weniger als 2 mg/l.