In vitro efficacy of sulbactam combined with ampicillin against anaerobic bacteria
Open Access
- 1 May 1985
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 27 (5) , 876-878
- https://doi.org/10.1128/aac.27.5.876
Abstract
An ampicillin-sulbactam combination was compared with ampicillin alone, chloramphenicol, clindamycin, and metronidazole against 272 strains of anaerobic bacteria. Chloramphenicol and ampicillin-sulbactam were the most effective, inhibiting 98 to 99% of strains tested at breakpoint (16 micrograms/ml). The combination of sulbactam and ampicillin was much more effective than ampicillin alone against Bacteroides fragilis strains but did not differ substantially from ampicillin alone against Fusobacterium spp., gram-positive rods, and gram-positive cocci.Keywords
This publication has 13 references indexed in Scilit:
- Pharmacokinetics of sulbactam in humansAntimicrobial Agents and Chemotherapy, 1983
- Differences in susceptibilities of species of the Bacteroides fragilis group to several beta-lactam antibiotics: indole production as an indicator of resistanceAntimicrobial Agents and Chemotherapy, 1982
- Activity of cefoperazone and two beta-lactamase inhibitors, sulbactam and clavulanic acid, against Bacteroides spp. correlated with beta-lactamase productionAntimicrobial Agents and Chemotherapy, 1982
- In-vitro evaluation of sulbactam, a penicillanic acid sulphone with β-lactamase inhibitory propertiesJournal of Antimicrobial Chemotherapy, 1982
- The effect of inhibitors of β-lactamases on β-lactamase extracts and on intact cellsJournal of Antimicrobial Chemotherapy, 1982
- CP-45,899 in combination with penicillin or ampicillin against penicillin-resistant Staphylococcus, Haemophilus influenzae, and BacteroidesAntimicrobial Agents and Chemotherapy, 1980
- CP-45,899, a Beta-Lactamase Inhibitor That Extends the Antibacterial Spectrum of Beta-Lactams: Initial Bacteriological CharacterizationAntimicrobial Agents and Chemotherapy, 1978
- Susceptibility of Anaerobic Bacteria to 23 Antimicrobial AgentsAntimicrobial Agents and Chemotherapy, 1976
- Identification and Antimicrobial Susceptibility of 250 Bacteroides fragilis Subspecies Tested by Broth Microdilution MethodsAntimicrobial Agents and Chemotherapy, 1976
- Antibiotic Susceptibility of the Subspecies of Bacteroides fragilisAntimicrobial Agents and Chemotherapy, 1976