Random Sequence Mutagenesis and Resistance to 5-Fluorouridine in Human Thymidylate Synthases
Open Access
- 1 October 1998
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 273 (40) , 25809-25817
- https://doi.org/10.1074/jbc.273.40.25809
Abstract
No abstract availableKeywords
This publication has 25 references indexed in Scilit:
- Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active siteBiochemistry, 1995
- Mechanism-Based Inhibition of Thymidylate Synthase by 5-(Trifluoromethyl)-2'-deoxyuridine 5'-MonophosphateBiochemistry, 1994
- Structure-Based Discovery of Inhibitors of Thymidylate SynthaseScience, 1993
- Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinonesJournal of Medicinal Chemistry, 1993
- Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2′-deoxyuridylate and 10-propargyl-5,8-dideazafolateJournal of Molecular Biology, 1990
- Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folateBiochemistry, 1990
- Thymidylate synthase: A target for anticancer drug designAdvances in Enzyme Regulation, 1989
- Atomic Structure of Thymidylate Synthase: Target for Rational Drug DesignScience, 1987
- Methotrexate-induced misincorporation of uracil into DNAProceedings of the National Academy of Sciences, 1980
- STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLIProceedings of the National Academy of Sciences, 1954