Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2′-deoxyuridylate and 10-propargyl-5,8-dideazafolate
- 1 August 1990
- journal article
- research article
- Published by Elsevier in Journal of Molecular Biology
- Vol. 214 (4) , 923-936
- https://doi.org/10.1016/0022-2836(90)90346-n
Abstract
No abstract availableThis publication has 35 references indexed in Scilit:
- Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolateJournal of Molecular Biology, 1990
- Stacked beta-bulges in thymidylate synthase account for a novel right-handed rotation between opposing beta-sheetsJournal of Molecular Biology, 1989
- Conformational analysis of antineoplastic antifolates: the crystal structure of trimetrexate and the aminopterine derivative 4-[N-[(2,4-diamino-6-pteridinyl)methyl]amino]benzoic acidJournal of Medicinal Chemistry, 1987
- Folate analogs as inhibitors of thymidylate synthaseJournal of Medicinal Chemistry, 1987
- Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituentJournal of Medicinal Chemistry, 1985
- Fluorine-19 nuclear magnetic resonance investigation of the noncovalent and covalent binary complexes of 5-fluorodeoxyuridylate and Lactobacillus casei thymidylate synthetaseBiochemistry, 1980
- Substrate specificity of bacterial thymidylate-synthetaseCollection of Czechoslovak Chemical Communications, 1974
- Molecular and crystal structure of the tRNA minor constituent dihydrouridineActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1972
- Stereochemistry of nucleic acids and their constituents. VI. The crystal structure and conformation of dihydrouracil: a minor base of transfer-ribonucleic acidActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1970
- The stability of helical polynucleotides: Base contributionsJournal of Molecular Biology, 1962