Antibiotic Activity of Subtilin and Streptomycin in the Presence of BAL

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Abstract
A study was made of 4 strains of Mycobacterium, 2 human strains- (H37Rv and Rl), 1 bovine, and 1 nonpathogenic #599, and a strain of Micrococcus lysodeikticus. The latter was cultured in beef heart infusion medium, and tests were made in the same medium. Mycobacteria were cultured in Dubos'' medium and tested therein. BAL was used in a dilution of 1:100,000. BAL was found to be synergistic with subtilin in bacteriostatic action on all strains of mycobacteria but not on M. lysodeikticus. The bacteriostatic activity of streptomycin against pathogenic mycobacteria was potentiated, though less remarkably than subtilin. Its action was not affected against strain #599. Streptomycin was inactivated in the presence of BAL against M. lysodeikticus. The mechanism of synergism between subtilin and BAL is unknown.