Intercellular heterogeneity of expression of the MGMT DNA repair gene in pediatric medulloblastoma
Open Access
- 1 July 2004
- journal article
- Published by Oxford University Press (OUP) in Neuro-Oncology
- Vol. 6 (3) , 200-207
- https://doi.org/10.1215/s1152851703000565
Abstract
DNA methylation and epigenetic inactivation of the O6-methylguanine methyltransferase (MGMT) gene induces MGMT deficiency, reducing the tumor cell'sKeywords
This publication has 28 references indexed in Scilit:
- A comparative immunohistochemistry of O6-methylguanine-DNA methyltransferase and p53 in diffusely infiltrating astrocytomasNeuropathology, 2003
- Inactivation of O6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancersBritish Journal of Cancer, 2002
- Enforced expression of wild-type p53 curtails the transcription of the O-6-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents2001
- O6-Methylguanine-DNA methyltransferase in pediatric primary brain tumors: relation to patient and tumor characteristics.2001
- Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.2000
- Confluence-induced alterations in CpG island methylation in cultured normal human fibroblasts.Nucleic Acids Research, 1999
- Expression of O6-methylguanine-DNA methyltransferase in six human medulloblastoma cell lines.1992
- EXPRESSION OF THE O-6-METHYLGUANINE-DNA METHYLTRANSFERASE GENE MGMT IN MER+ AND MER- HUMAN TUMOR-CELLS1990
- A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year resultsJournal of Neurosurgery, 1989
- Long‐term sequelae of cancer treatment on the central nervous system in childhoodMedical and Pediatric Oncology, 1987