Identification of Mutations Related to Streptomycin Resistance in Clinical Isolates of Mycobacterium tuberculosis and Possible Involvement of Efflux Mechanism
- 1 August 2008
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (8) , 2947-2949
- https://doi.org/10.1128/aac.01570-07
Abstract
The MIC for streptomycin in the presence of efflux pump (EP) inhibitors and the sequencing of rpsL , rrs , and gidB genes provided evidence for the possible participation of EP in low-level streptomycin (STR) resistance of some isolates without mutations. Mutation in the gidB gene and an EP could act synergistically to confer low STR resistance.Keywords
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