Absorption and Metabolism of Bayer 22408 by Dairy Cows and Residues in the Milk1

Abstract
P32-labeled Bayer 22408 (O,O-diethyl O-naphthalimido phosphorothioate) was applied dermally as a 0.5% emulsion to two Holstein dairy cows. Detectable quantities of the intact insecticide were isolated from the milk the first 6 days after treatment. Bayer 22408 equivalents in the milk were about 10 times higher than the actual Bayer 22408. No oxygen analog of the parent compound was isolated from milk, but it was the predominant nonhydrolyzed product of the feces. The fecal metabolites were toxic to stable fly (Stomoxys calcitrans (L.)) larvae, but not to house fly (Musca domestica L) larvae.

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