DRUG FOCUS: Pharmacogenetic Studies Related to Cyclophosphamide-Based Therapy
- 3 December 2009
- journal article
- research article
- Published by Taylor & Francis in Pharmacogenomics
- Vol. 10 (12) , 1897-1903
- https://doi.org/10.2217/pgs.09.134
Abstract
Cyclophosphamide is a cornerstone in the treatment of many pediatric and adult malignancies, as well as in the treatment of refractory autoimmune conditions. Genetic factors are thought to play a role in the interindividual variation in both response and toxicities associated with cyclophosphamide-based therapies. This drug focus reviews the most compelling studies conducted on the pharmacogenetics of cyclophosphamide-based therapies. Broader pharmacogenomic studies are needed and may reveal additional factors important in susceptibility to toxicity and/or response to therapy.Funding Information
- Pharmacogenetics of Anticancer Agents Research (U01GM61393, P50 CA125183, RO1 CA81485)
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