4′-Modification of carbocyclic nucleosides: synthesis of 4′-α-fluoro, 4′α-hydroxy and 4′,6′-unsaturated derivatives of the antiviral agent 2′-ara-fluoro carbocyclic guanosine
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 19,p. 1380-1382
- https://doi.org/10.1039/c39900001380
Abstract
4′-α-Fluoro 13, 4′-α-hydroxy 11, and 4′,6′-unsaturated 15 derivatives of (±) 2′-ara-fluoro carbocylci guanosine 1 are prepared via the 4′,5′-alkene 8.Keywords
This publication has 10 references indexed in Scilit:
- Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracilJournal of Medicinal Chemistry, 1990
- Synthesis of compounds active against HIV. Part 2. Preparation of some 2′,3′-dideoxy-6′-fluorocarbocyclic nucleosidesJournal of the Chemical Society, Chemical Communications, 1990
- Synthetic studies towards (−)-carba-3′-deoxy-3′-fluorothymidine.Tetrahedron, 1989
- Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolaseJournal of Medicinal Chemistry, 1988
- Synthesis and enzymatic resolution of carbocyclic 2′-ara-fluoro-guanosine: a potent new anti-herpetic agentJournal of the Chemical Society, Chemical Communications, 1988
- Carbocyclic nucleosidesMedicinal Research Reviews, 1986
- On stereochemistry of osmium tetraoxide oxidation of allylic alcohol systems. Empirical ruleTetrahedron, 1984
- Studies on neplanocin a, new antitumor antibiotic. I. Producing organism, isolation and characterization.The Journal of Antibiotics, 1981
- Halo sugar nucleosides. I. Iodination of the primary hydroxyl groups of nucleosides with methyltriphenoxyphosphonium iodideThe Journal of Organic Chemistry, 1970
- Structure of nucleocidin. III. revised structureJournal of the American Chemical Society, 1969