Experimental Leptospirosis: The Early Pathogenesis of Leptospira Pomona Infection in Young Swine

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Abstract
Demonstrable microscopic renal lesions were present by day 4. These early lesions consisted primarily of an intertubular leucocytic infiltration with lymphocytes the predominant inflammatory cell. Gross kidney lesions, consisting of grayish-white foci on the cortical surface, appeared on day 7 and were extensive by day 9. Microscopic brain lesions were present by day 11. The meningoencephalitis was characterized by peri-vascular lymphocytic infiltrations in the cerebrum. Hematological values were only slightly altered from normal determinations. Sero-logical and clinical findings substantiated previous experimental evidence.