Hepatitis A Vaccine

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Abstract
The first effective control measures for the prevention of enterically transmitted viral hepatitis resulted from research conducted during World War II. In 1945, Neefe et al.1 demonstrated that infectious virus could be transmitted by contaminated drinking water, that treatment of the water by filtration and chlorination made it safe to drink, and that gamma globulin derived from convalescent-phase serum from patients with hepatitis could protect adults from clinical hepatitis.2 Except for refinements in methods of preparing food and water and the establishment of standards for the preparation and use of immune globulin, there have been no fundamental improvements in the . . .