A Two-step Procedure for the Purification of Hepatitis B Surface Antigen (HBsAg)

Abstract
Hepatitis B surface antigen (HBsAg) was purified by a simple, rapid, two-step procedure comprising chromatography on dextran sulfate-Sepharose 4B, followed by preparative rate zonal centrifugation on a sucrose gradient. A 230-fold purification of HBsAg was achieved with a yield of about 80%.

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