Advanced Ovarian Cancer: A Prospective Randomised Trial of Chlorambucil Versus Combined Cyclophosphamide and Cis-diamminedichloroplatinum

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Abstract
Thirty-seven patients with advanced ovarian cancer were treated in a prospective, randomized trial comparing chlorambucil with a combination of cyclophosphamide and cis-diamminedichloroplatinum (cis-DDP). Treatment with the combination was associated with an increased overall response rate (69% vs. 23%) (P = 0.04). A response was associated with a longer median survival, but no survival advantage was demonstrated for patients who received cyclophosphamide/cis-DDP. A larger study is needed to evaluate fully the potential of regimens containing cis-DDP in the management of advanced ovarian cancer.