A new warfarin metabolite: structure and function
- 30 September 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (10) , 1054-1059
- https://doi.org/10.1021/jm00208a009
Abstract
The metabolism of the clinically utilized, anticoagulant warfarin [4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one] by rat liver microsomes was investigated. The structure of a new warfarin metabolite [4-hydroxy-3-(3-oxo-1-phenyl-1-butenyl)-2H-1-benzopyran-2-one] (dehydrowarfarin) was determined by mass spectral comparison with the chemically synthesized compound. Formation of dehydrowarfarin was catalyzed by cytochrome P-450 and was unusual in that the final product was effectively dehydrogenated warfarin.This publication has 9 references indexed in Scilit:
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