Physicians' Health Study: Aspirin and Primary Prevention of Coronary Heart Disease

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To the Editor: Both the U.S. Physicians' Health Study (July 20 issue)1 and the British Doctors' Study2 found no significant differences in mortality from all causes or from cardiovascular disease between aspirin-treated and placebo or untreated groups. The British study also found no differences in event rates for nonfatal or fatal myocardial infarction. In contrast, the U.S. study reported a significant reduction in rates of nonfatal and fatal myocardial infarction in the aspirin-treated group, leading to the authors' conclusion that aspirin treatment is protective overall against coronary heart disease.In the U.S. study, although the death rates for acute myocardial . . .