The Effects of L-Thyroxine Sodium on Nontoxic Goiter, on Myxedema and on the Thyroid Uptake of Radioactive Iodine

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Abstract
SYNTHETIC thyroxine is apparently absorbed and physiologically active when ingested, although it has generally been used intravenously.1 2 3 4 5 6 Clinical studies employing oral administration of 1-thyroxine sodium have demonstrated its effectiveness in treating and maintaining athyreotic patients.5 , 6 The possible advantages inherent in a therapeutic agent of constant potency and composition have prompted further clinical evaluation of 1-thyroxine sodium in patients with myxedema. In addition, we have studied the suppressive effect of 1-thyroxine administration on the thyroid uptake of radioactive iodine, as well as its influence on the size of nontoxic goiters.MethodsUptakes of radioactive iodine were determined in 7 patients with . . .