Modification of the Radiation Effect on the Reproductive Capacity of Tumor Cells in Vivo with Pharmacological Agents

Publisher Website
Google Scholar
Abstract
The reproductive capacity of tumor cells from the ascites P-388 leukemia of the DBA/2 strain mouse was studied after treatment with 5-Iododeoxyuridine (IUdR) or 5-Bromodeoxyuridine (BUdR) and/or X-irradiation Experimental criteria werethe numbers of leukemic cells from control and variously treated tumor-bearing donor animals necessary to produce 50% takes in a group of recipient mice of the same strain. At doses of 300 mg/kg/day for 4 days, IUdR alone did not affect the reproductive capacity of leukemic cells but markedly enhanced radiation effects upon them (i.e., decreased the number of cells reproductively intact after given single X-ray doses). The amount of radiation potentiation was proportional to the dose of IUdR used. BUdR alone produced a moderate inhibition of tumor cell reproductive capacity but also potentiated radiation effect at low drug dose levels.

This publication has 4 references indexed in Scilit: