B cell infiltration of the thymic medulla in new zealand black, new zealand white, and (new zealand black × new zealand white)f1 mice

Open Access
Publisher Website
Google Scholar
Abstract
Thymuses from female (New Zealand black × New Zealand white)F1 ([NZB × NZW]F1), New Zealand black, and New Zealand white mice of different ages were examined by immunohistochemical and flow cytometric analysis. Two‐and‐a‐half‐month‐old (NZB × NZW)F1 mice showed infiltration of the thymus with B cells, and by 6–8 months of age, showed a disruption of the entire medullary area. More than 80% of the thymic B cells had the phenotypic characteristics of conventional B cells (IgM+, IgD+, Ly‐1—). Total lymphoid irradiation induced a marked depletion of medullary B cells and a restoration of the thymic architecture.