Secretion of Sulfonamides in Milk Following Intramammary Oral and Parenteral Administrations

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Abstract
Commercial preparations of sulfonamides were administered to lactating dairy cows. Neoprotosil injected intramuscularly (240 gr./cow) was not detected in milk during the subsequent 24 hr. Intravenous injection of sulfabrom (0.25 gr./lb. body wt), suljex (772 gr./cow) and sulfamerazine (0.5 and 1.0 gr./lb. body wt) resulted in detectable residues for a maximum of 21, 38, 54 and 54 hr., respectively. Residue was detectable a maximum of 45 hr. after intrauterine infusion of 77 gr. of sulfaurea. Orally administered sulfonamides, dose in gr./lb. body weight, and the maximum duration of detectable residues in milk were sulfonilamide, (1.0 gr., 86 hr.); sulfadiazine, (0.5 gr., 62 hr.); and sulfamerazine, (0.5 gr. 60 hr.). Following intramammary infusion of sulfamerazine (80 gr./quarter), the drug residue was detected a maximum of 24 hrs.
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