SURVIVAL TIME AS A RAPID METHOD OF DETERMINING VIRULENCE WITHBACILLUS ANTHRACIS

1 November 1956

journal article
research article
Published by American Society for Microbiology in Journal of Bacteriology

Vol. 72 (5) , 666-672
https://doi.org/10.1128/jb.72.5.666-672.1956

Abstract

By 3 methods of determining virulence (ST50, LD50, and in vitro tests), it was shown that one strain of B. anthracis is more virulent than a 2d strain. Survival time of mice is suggested as a convenient and rapid method of determining virulence with B. anthracis. Significant differences were found in survival times of animals challenged with 2 strains at various doses. Homogeneity of animals is required for good survival time determinations. The median survival time for half the animals in a given treatment (ST50) is proposed as the unit of measure. Two alternate methods for determining ST50''s are presented.

Keywords

BACILLUS ANTHRACIS

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