High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites

This publication has 12 references indexed in Scilit:

• High-throughput Caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry
  Rapid Communications in Mass Spectrometry, 2000
• Determination ofin vitro permeability of drug candidates through a Caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry
  Journal of Mass Spectrometry, 2000
• High-Throughput Bioanalytical LC/MS/MS Determination of Benzodiazepines in Human Urine: 1000 Samples per 12 Hours
  Analytical Chemistry, 1999
• Use of “N-in-one” Dosing to Create an in Vivo Pharmacokinetics Database for use in Developing Structure—Pharmacokinetic Relationships
  Journal of Pharmaceutical Sciences, 1999
• Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential
  Xenobiotica, 1999
• The use of high-flow high performance liquid chromatography coupled with positive and negative ion electrospray tandem mass spectrometry for quantitative bioanalysis via direct injection of the plasma/serum samples
  Rapid Communications in Mass Spectrometry, 1998
• Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes
  British Journal of Clinical Pharmacology, 1998
• High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation
  Rapid Communications in Mass Spectrometry, 1998
• Rapid Determination of Oral Pharmacokinetics and Plasma Free Fraction Using Cocktail Approaches: Methods and Application
  Pharmaceutical Research, 1998
• P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature
  Pharmacogenetics, 1996