Mechanisms and consequences of paternally‐transmitted chromosomal abnormalities
- 1 June 2005
- journal article
- review article
- Published by Wiley in Birth Defects Research Part C: Embryo Today: Reviews
- Vol. 75 (2) , 112-129
- https://doi.org/10.1002/bdrc.20040
Abstract
Paternally‐transmitted chromosomal damage has been associated with pregnancy loss, developmental and morphological defects, infant mortality, infertility, and genetic diseases in the offspring, including cancer. There is epidemiological evidence linking paternal exposure to occupational or environmental agents with an increased risk of abnormal reproductive outcomes. There is also a large body of literature on germ cell mutagenesis in rodents showing that treatment of male germ cells with mutagens has dramatic consequences on reproduction, producing effects such as those observed in human epidemiological studies. However, we know very little about the etiology, transmission, and early embryonic consequences of paternally‐derived chromosomal abnormalities. The available evidence suggests that: 1) there are distinct patterns of germ cell–stage differences in the sensitivity of induction of transmissible genetic damage, with male postmeiotic cells being the most sensitive; 2) cytogenetic abnormalities at first metaphase after fertilization are critical intermediates between paternal exposure and abnormal reproductive outcomes; and 3) there are maternal susceptibility factors that may have profound effects on the amount of sperm DNA damage that is converted into chromosomal aberrations in the zygote and that directly affect the risk for abnormal reproductive outcomes. Birth Defects Research (Part C) 75:112–129, 2005.Keywords
This publication has 165 references indexed in Scilit:
- Human Gene Mutation Database (HGMD®): 2003 updateHuman Mutation, 2003
- Lessons learned from epidemiologic studies of environmental exposure and genetic diseaseEnvironmental and Molecular Mutagenesis, 1995
- Induction of specific-locus and dominant lethal mutations in male mice by busulfanMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1991
- Concentration‐response curves for ethylene‐oxide‐induced heritable translocations and dominant lethal mutationsEnvironmental and Molecular Mutagenesis, 1990
- Mechanism of chromosome aberration induction in the mouse egg fertilized with sperm recovered from postmeiotic germ cells treated with methyl methanesulfonateMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989
- X-ray- and mitomycin C (MMC)-induced chromosome aberrations in spermiogenic germ cells and the repair capacity of mouse eggs for the X-ray and MMC damageMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989
- Chromosomal analysis in mouse eggs fertilized in vitro with sperma exposed to ultraviolet light (UV) and methyl and ethyl methanesulfonate (MMS and EMS)Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1988
- Studies on chromosome aberrations in the eggs of mice fertilized in vitro after irradiation I. Chromosome aberrations induced in sperm after X-irradiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1985
- New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. I. Modification of the heritable translocation testTeratogenesis, Carcinogenesis, and Mutagenesis, 1981
- Expression of tem-induced damage to postmeiotic stages of spermatogenesis of the mouse during early embryogenesisMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978