Soluble Interfeukin-2 Receptors in Children with Juvenile Chronic Arthritis

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Abstract
Fassbender K., Michels H, Vogt P, Aeschlimann A, Müller W. Soluble Interleukin-2 Receptors in Children with Juvenile Chronic Arthritis. Scand J Rheumatol 1992; 21: 120–23. Concentrations of interleukin-2 receptors were studied in sera of 81 patients with pauciarticular-, polyarticular-, and systemic-onset juvenile chronic arthritis using a double antibody “sandwich” enzyme-linked immuno sorbent technique. Serum concentrations were significantly increased in all subgroups when compared with the healthy controls. Higher concentrations were found in systemic onset disease than in pauci or polyarticular onset disease. Serum levels were found to be increased in both inactive and active disease, showing maximal values in patients with systemic features. A correlation to C-reactive protein, alpha,-acid glycoprotein, and erythrocyte sedimentation was observed. Increased sIL2R values suggest disease activity despite the absence of clinical symptoms.