Regenerating gene expression in normal gastric mucosa and indomethacin-induced mucosal lesions of the rat

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Abstract
Regenerating (reg) gene expression was tested in rat gastrointestinal mucosa to investigate the role played by this gene in the healing of mucosal lesions. Expression ofreg mRNA was higher in the stomach than in any other region of the gastrointestinal tract. The gastric cells that expressedreg mRNA were located in the deepest mucosal layer and were small in diameter. In an injured state following indomethacin treatment,reg gene expression was markedly augmented, accompanied by an increase of c-fos expression and healing of the mucosal lesions. These results suggest a role of thereg gene in the healing of gastrointestinal mucosal lesions.