Integrity of the cytoskeletal system is important for phagocytosis by Kupffer cells
- 1 August 1990
- journal article
- research article
- Published by Wiley in Liver International
- Vol. 10 (4) , 249-254
- https://doi.org/10.1111/j.1600-0676.1990.tb00466.x
Abstract
— The mechanism of phagocytosis by Kupffer cells is believed to involve the Ca2+-calmodulin system. However, the role of myosin in this system is still unknown. In this study, we found that myosin light chain kinase inhibitor (ML-9) inhibited phagocytosis by cultured Kupffer cells using polystyrene beads, a time-lapse VTR system and fluorescent staining techniques. The inhibitory effects of ML-9 suggest that myosin may be involved in this complex cellular function and that the integrity of the cytoskeletal system is essential for normal phagocytosis.Keywords
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