Estimation of Relative Changes in Resting Muscle Blood Flow by133Xe Washout: The Effect of Oxygen
- 1 January 1973
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 31 (2) , 133-139
- https://doi.org/10.3109/00365517309084301
Abstract
133Xe washout from resting anterior tibial muscle was studied in the 10 to 30-minute period after injection of 133Xe. The elimination curves were not strictly monoexponential, but presented a slight spontaneous decrease in rate constant during the period. An experimental design is presented which permits the detection of small, induced changes in muscle blood flow despite this spontaneous decrease in rate constant. Errors in the determination of resting muscle blood flow from 133Xe washout are discussed. It is concluded that relative changes in resting muscle blood flow may be overestimated when calculated from changes in 133Xe elimination rate constants. Oxygen breathing at 1 atm. was shown to reduce resting muscle blood flow.Keywords
This publication has 18 references indexed in Scilit:
- Shunting by Diffusion of Inert Gas in Skeletal MuscleActa Physiologica Scandinavica, 1972
- Effect of Oxygen Breathing on Local Blood Flow in Human Adipose TissueScandinavian Journal of Clinical and Laboratory Investigation, 1972
- Muscle blood flow during exercise in normal man studied by the 133Xenon clearance methodCardiovascular Research, 1971
- Effects of changes in PO2 and PCO2 and pH on the total vascular resistance of perfused cat kidneysThe Journal of Physiology, 1967
- Validity of the 133Xenon Method for Determination of Muscle Blood Flow in Man as Evaluated by Simultaneous Venous Occlusion Plethysmography during Intravenous Infusions of AdrenalineCardiovascular Research, 1967
- Venous Occlusion Plethysmography and133Xe Muscle Clearance Measured Simultaneously on the Calf in Normal SubjectsScandinavian Journal of Clinical and Laboratory Investigation, 1967
- The Relation Between Blood Flow in an Isolated Muscle Measured with the Xe133 Clearance and a Direct Recording TechniqueActa Physiologica Scandinavica, 1967
- Validity of the Xenon 133 Method for Measurement of Muscle Blood Flow Evaluated by Simultaneous Venous Occlusion PlethysmographyCirculation Research, 1965
- Measurement of Muscle Blood Flow in the Human Forearm with Radioactive Krypton and XenonCirculation, 1964
- THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN 1Journal of Clinical Investigation, 1948