EFFECT OF TIME OF ADMINISTRATION OF CHOLESTYRAMINE ON PLASMA-LIPIDS AND LIPOPROTEINS

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 13  (1) , 1-6
Abstract
Cholestyramine was administered to 15 men with type II hyperlipoproteinemia in a dosage of 8 gm twice daily. For each subject, the p.m. dose was randomly assigned to one of four approximate time periods: mid-afternoon, 30 minutes before the evening meal, 60 minutes after the evening meal, and at bedtime. The time of the morning dose remained constant throughout the study. Each treatment period lasted eight weeks, and all participants completed all four treatments assignments. There was a significant reduction of both total plasma cholesterol (TPC) and LDL cholesterol (LDL-C) compared to baseline values (p < 0.001) for all treatment regimens. TPC and LDL-C reduction was greatest when the p.m. dose was taken 30 minutes before the evening meal. This reduction was also significantly greater than when the p.m. dose was taken mid-afternoon (p < 0.05). There was also a significant increase in triglycerides compared to baseline during all treatment periods (p < 0.05).