Isolation of a novel arachidonic acid metabolite 3‐hydroxy‐5,8,11,14‐eicosatetraenoic acid (3‐HETE) from the yeast Dipodascopsis uninucleata UOFs‐Y128
- 3 June 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 283 (2) , 195-198
- https://doi.org/10.1016/0014-5793(91)80586-r
Abstract
When arachidonic acid (AA) is added to the yeast Dipodascopsis uninucleata UOFS Y128, one of the major metabolites isolated and purified with the help of thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) is 3‐hydroxy‐5,8,11,14‐eicosatetraenoic acid (3‐HETE). The structure of this new AA metabolite was elucidated mainly by electron impact (EI) mass spectrometry (MS). Strikingly, the formation of this new metabolite was found to be inhibited by aspirin.Keywords
This publication has 3 references indexed in Scilit:
- Removal of O-and N-benzyl groups by fungal biotransformationTetrahedron Letters, 1988
- Total synthesis of prostaglandins. IV. Completely stereospecific synthesis of prostaglandin E1Journal of the American Chemical Society, 1973
- 3-D-Hydroxypalmitic acid: a metabolic product of the yeast NRRL Y-6954Canadian Journal of Chemistry, 1968