DIETARY CONTROL OF SERUM CHOLESTEROL LEVELS IN RATS FED HIGH-FAT, CHOLATE-CONTAINING DIETS

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Abstract
In a series of experiments, rats were fed semisynthetic atherogenic diets containing variable amounts of cholesterol (from 0 to 5%) with 40% of either cocoa butter, dairy butter, corn oil, or linseed oil as the source of fat, and 2% sodium cholate. It was found that serum cholesterol levels increased as the amount of dietary cholesterol increased to the 1% level, but raising the dietary cholesterol above this level did not provoke a proportional change in serum cholesterol during the first 3 months of the experiment.