Visualization of Single-Stranded Nucleic Acid of RNA Tumor Virus With The Electron Microscope
- 1 May 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (5) , 1887-1890
- https://doi.org/10.1073/pnas.71.5.1887
Abstract
60-70S RNA of avian myeloblastosis virus was spread with the Kleinschmidt method and examined in the electron microscope after being subjected to a variety of denaturing conditions. Extension of the molecules from a collapsed configuration was seen only under stringent denaturing conditions, resulting in molecules of 1-2 mum in length. Longer strands of these extremely fragile molecules cannot be obtained with the methods presently available.Keywords
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