Toxic-Oil Syndrome

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To the Editor: The careful study by Kilbourne and colleagues (Dec. 8 issue)1 of the natural history of acute toxic-oil syndrome and its late severe neuromuscular sequelae made only one reference to the occurrence of pulmonary hypertension after the acute illness.We have documented the clinical, hemodynamic, echocardiographic, and pathological features in 38 of 465 patients admitted to the Hospital Provinciale de Madrid with the acute sindrome toxico who then returned within two months with clinical evidence of pulmonary hypertension and right-heart failure.2 The clinical findings in these patients on admission included new exertional dyspnea (76 per cent), a prominent . . .

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