Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase
- 15 January 2006
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 16 (2) , 391-394
- https://doi.org/10.1016/j.bmcl.2005.09.077
Abstract
No abstract availableKeywords
This publication has 19 references indexed in Scilit:
- Substrate Recognition and Channeling of Monomodules from the Pikromycin Polyketide SynthaseJournal of the American Chemical Society, 2003
- Expression and Kinetic Analysis of the Substrate Specificity of Modules 5 and 6 of the Picromycin/Methymycin Polyketide SynthaseJournal of the American Chemical Society, 2003
- Expression, Site-Directed Mutagenesis, and Steady State Kinetic Analysis of the Terminal Thioesterase Domain of the Methymycin/Picromycin Polyketide SynthaseBiochemistry, 2002
- The Hidden Steps of Domain Skipping: Macrolactone Ring Size Determination in the Pikromycin Modular Polyketide SynthaseChemistry & Biology, 2002
- Elucidating the mechanism of chain termination switching in the picromycin/methymycin polyketide synthaseChemistry & Biology, 1999
- Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthaseChemistry & Biology, 1999
- A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae : Architecture of metabolic diversityProceedings of the National Academy of Sciences, 1998
- Isolation and characterization of 10-deoxymethynolide produced by Streptomyces venezuelae.The Journal of Antibiotics, 1992
- The biosynthesis of picromycin using 13C enriched precursors.The Journal of Antibiotics, 1976
- Isolation and structure of narbonolide, narbomycin aglycone, from Streptomyces venezuelae and its biological transformation into picromycin via narbomycinJournal of the Chemical Society D: Chemical Communications, 1971