NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases
- 8 January 2008
- journal article
- review article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 114 (3) , 173-182
- https://doi.org/10.1042/cs20070130
Abstract
Oxidative stress plays a key role in the pathophysiology of several major cardiovascular diseases, including atherosclerosis, hypertension, heart failure, stroke and diabetes. ROS (reactive oxygen species) affect multiple tissues either directly or through NO depletion. ROS induce cardiovascular dysfunction by modulating cell contraction/dilation, migration, growth/apoptosis and extracellular matrix protein turnover, which contribute to vascular and cardiac remodelling. Of the several sources of ROS within the cardiovascular system, a family of multisubunit NADPH oxidases appears to be a predominant contributor of superoxide anion. Recent findings suggest a significant role of the genetic background in NADPH oxidase regulation. Common genetic polymorphisms within the promoter and exonic sequences of CYBA, the gene that encodes the p22(phox) subunit of NADPH oxidase, have been characterized in the context of cardiovascular diseases. This review aims to present the current state of research into these polymorphisms in their relationship to cardiovascular diseases.Keywords
This publication has 102 references indexed in Scilit:
- The p22phox C242T gene polymorphism is associated with a reduced risk of angiographically verified coronary artery disease in a high-risk Finnish Caucasian population. The Finnish Cardiovascular StudyAmerican Heart Journal, 2006
- Endothelial Protection, AT 1 Blockade and Cholesterol-Dependent Oxidative StressCirculation, 2006
- Novel isoforms of NADPH-oxidase in cerebral vascular controlPharmacology & Therapeutics, 2006
- Oxidative Stress and Vascular DiseaseArteriosclerosis, Thrombosis, and Vascular Biology, 2005
- Functional Effect of the
p22
phox
−930 A/G Polymorphism on p22 phox Expression and NADPH Oxidase Activity in HypertensionHypertension, 2004
- C242T CYBA Polymorphism of the NADPH Oxidase Is Associated With Reduced Respiratory Burst in Human NeutrophilsHypertension, 2004
- Endothelin Antagonism on Aldosterone-Induced Oxidative Stress and Vascular RemodelingHypertension, 2003
- Preliminary characterisation of the promoter of the human p22phox gene: identification of a new polymorphism associated with hypertensionFEBS Letters, 2003
- Oxidative Stress in Arterial HypertensionHypertension, 2001
- Vascular NADH/NADPH Oxidase Is Involved in Enhanced Superoxide Production in Spontaneously Hypertensive RatsHypertension, 2000