Effect of catecholamines on somatostatin secretion by isolated perfused rat stomach

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Abstract
The secretion of somatostatin-like immunoreactivity (SRIF-LI) by the isolated perfused rat stomach was studied in response to stimulation by catecholamines. Gastric SRIF-LI secretion was significantly stimulated in a dose-dependent manner by norepinephrine [NE] at 10-6 and 10-8 M and the effect of NE (10-8 M) was attenuated by the addition of propranolol (10-6) by dopamine at concentrations of 10-4 and 10-6 M but not at 10-8 M. The effect of dopamine (10-6 M) was not altered by the addition of haloperidol (10-4 to 10-7 M) or metoclopramide (10-4 M) and bromocriptine (10-6 M) was without effect on SRIF-LI secretion. Gastric SRIF-LI secretion is apparently stimulated by a .beta.-adrenergic mechanism and raises the possibility that gastric somatostatin contributes to the inhibitory effect of NE on gastric acid secretion.