Systemic Arterial Blood pH Servocontrol of Mechanical Ventilation

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Abstract
Servocontrol of mechanical ventilation using systemic arterial blood pH, measured by a dual-function pH/PCO2 [partial pressure of CO2] intra-arterial sensor, as the controlled variable was carried out in 30 dogs anesthetized with pentobarbital, 30 mg/kg. The control loop consisted of the animal, an intra-arterial dual-function pH/PCO2 sensor and sensor amplifier, a controller, and a Siemans-Elema 900 servoventilator. The system responded appropriately to changes in set-point pH from 7.30-7.50, as well as to infusions of lactic acid, which, with the control loop open, decreased systemic arterial blood pH 0.1-0.2 pH units. Long-term (16 h) ventilation of 1 dog with the systemic arterial blood pH servocontrol ventilator was shown to be feasible.

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