A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes
- 15 February 1996
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 314 (1) , 27-32
- https://doi.org/10.1042/bj3140027
Abstract
Apoptosis induced in primary hepatocytes by transforming growth factor β1 and staurosporine produces chromatin condensation, DNA cleavage as detected by in situ end-labelling, field inversion and conventional gel electrophoresis, and cell detachment. These effects were abolished by benzyloxycarbonylvalinylalanylaspartylfluoromethyl ketone, a cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases, and this finding suggests that these enzymes are involved in liver apoptosis.Keywords
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