METHYLALLOPSORALEN‐THYMINE 3,4‐ and 4',5'‐MONOADDUCTS FORMED IN THE PHOTOREACTION WITH DNA
- 1 October 1985
- journal article
- research article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 42 (4) , 361-366
- https://doi.org/10.1111/j.1751-1097.1985.tb01582.x
Abstract
Abstract—Two new allopsoralens, i.e. 4,7.5'‐trimethylallopsoralen and 4,7,4'‐trimethylallopsoralen have been irradiated (365 nm) in the presence of DNA. The DNA so treated was hydrolyzed and among the products of its hydrolysis new 3,4‐ and 4',5'‐monocycloadducts between the two furocoumarins and thymine have been isolated. The monoadducts have been characterized on the basis of their spectroscopic properties, of their capacity to undergo photoreversion forming the parent compounds and of the NMR data. Acis‐synconformation has been suggested for both 3,4‐ and both 4',5'‐monoadducts.This publication has 12 references indexed in Scilit:
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