FURTHER IMPROVEMENTS OF OLIGODEOXYRIBONUCLEOTIDES SYNTHESIS: SYNTHESIS OF TETRADEOXYADENYLATE ON A NEW SILICA GEL SUPPORT USING N6-PHTHALOYLDEOXYADENOSINE
- 5 October 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 12 (10) , 1597-1600
- https://doi.org/10.1246/cl.1983.1597
Abstract
Introduction of a long alkyl chain between the nucleoside and the silica gel support was effective in DNA synthesis via the phosphotriester method. dApApApA containing 3′-terminal deoxyadenosine was successfully synthesized on the support by using N6-phthaloyldeoxyadenosine.Keywords
This publication has 19 references indexed in Scilit:
- Polymer support oligonucleotide synthesis 13: Rapid and efficient synthesis of oligodeoxynucleotides on porous glass support using triester approachTetrahedron Letters, 1983
- Silica gel: an improved support for the solid-phase phospphotriester synthesis of oligonucleotidesNucleic Acids Research, 1982
- Semiautomated synthesis of oligonucleotides on a silica gel supportTetrahedron Letters, 1982
- Phosphotriester synthesis of DNA fragments on cellulose and polystyrene solid supportsRecueil des Travaux Chimiques des Pays-Bas, 1982
- Recovery and recycling of synthetic units in the construction of oligodeoxyribonucleotides on solid supportsTetrahedron Letters, 1981
- Synthesis of deoxyoligonucleotides on a polymer supportJournal of the American Chemical Society, 1981
- Synthesis of oligodeoxyribonucleotides on silica gel supportNucleic Acids Research, 1981
- Rapid synthesis of oligodeoxyribonucleotides IV. Improved solid phase synthesis of oligodeoxy-ribonucleotides through phosphotriester intermediatesNucleic Acids Research, 1980
- Solid-phase synthesis of polynucleotides. III. Synthesis of polynucleotides with defined sequences by the block coupling phosphotriester methodNucleic Acids Research, 1980
- Solid phase phosphotriester synthesis of large oligodeoxyribonucleotides on a polyamide supportNucleic Acids Research, 1980