Comparative Susceptibility of Common Laboratory Animals to Experimental Infection with Schistosoma haematobium

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Abstract
Albino mice, Syrian hamsters, albino rats, guinea pigs and rabbits were exposed to known numbers of cercariae of S. haematobium. Only mice and hamsters were susceptible. Mice exposed to 150 cercariae each yielded an average of 5.3 worms (3.5% of the cercariae employed). Hamsters deposed to 200 cercariae each yielded an average of 33.8 worms per hamster (16.9% of the cercariae employed). In mice the worms reached maturity between 12 and 14 weeks after exposure but more than 50% of the worms remained in the liver. In hamsters the worms reached maturity at 10 weeks and a greater proportion of worms migrated to the mesenteric circulation. In both mice and hamsters, intestinal egg lesions were essentially limited to the ileum and colon. In hamsters, colonic egg lesions were most numerous in the ascending and transverse colon. Viable eggs were first found in the feces of mice 15 wks. after exposure, in hamsters after 10 wks.

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