Synaptic Mechanism of Pentylenetetrazole: Selectivity for Chloride Conductance
- 26 August 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 197 (4306) , 912-914
- https://doi.org/10.1126/science.887932
Abstract
In the neurons ofAplysia californicapentylenetetrazole (2 millimolar) greatly reduced chloride-dependent responses to the iontophoresis of putative transmitters. At the same concentration, pentylenetetrazole caused less attenuation of the other iontophoretic responses and had minimal membrane effects. Several convulsants have been observed to have a similar selectivity for the chloride conductance. A common mechanism of convulsant action—reduction of transmitter-induced chloride conductances—is hypothesized.This publication has 24 references indexed in Scilit:
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