SUPPRESSION OF CELL-MEDIATED ANTI-TUMOR IMMUNITY BY COMPLETE FREUNDS-ADJUVANT

  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (8) , 3215-3219
Abstract
The effect of complete Freund''s adjuvant (CFA), which is one of the strong immunoadjuvants, on the induction of either cytotoxic or suppressor T-cells against syngeneic tumors was investigated by an in vitro assay system. CFA did not show the apparent augmenting activity in the induction of cytotoxic T-cells against syngeneic tumors when it was administered i.p. to mice receiving s.c. inoculations of mitomycin C-treated tumor cells. The treated animals failed to develop stronger resistance against the 2nd inoculum of the same viable tumor cells. CFA had an effect on the induction of suppressor T-cells in tumor-bearing hosts in which suppressor T-cells had been readily activated. Suppressor T-cells developed in syngeneic tumor-bearing mice treated with CFA were tumor specific. Tumor growth was enhanced when CFA was administered to mice given s.c. inoculations of the homologous tumor.